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Altretamine

Altretamineis an oral cancer medication. It is prescribed for the treatment of recurrentovarian cancer. It interferes with the growth of cancer cells and prevents thecancer cells from spreading in the body.  Altretamine is FDA approved for the treatment andrelieving the symptoms of ovarian cancer since 1990. It is usually given afterother cancer medications were ineffective. It may also be used for the purposesas determined by your physician.

Altretamineis an antineoplastic agent. The exact mechanism of action remains unknown.Since it is an antineoplastic agent, it metabolizes into alkylating agents byN-demethylation.  These agents can causedamages to the tumor cells.

How to use Altretamine?

TakeAltretamine exactly as directed. The recommended dose of this medication is 1tablet 4 times a day. It is given in a 28-day treatment cycle. Take yourmedication only during the first 2 or 3 weeks of each cycle or as determined byyour doctor.  Take your medication aftereach meal and before bedtime with enough water. Do not take more than what isprescribed or longer than the recommended duration of treatment. For a misseddose, contact your doctor right away. In case of an overdose, seek medical attentionright away.

What are the side effects of Altretamine?

Some commonside effects are:

  • Temporary hair loss
  • Mild to moderate nausea
  • Rash and itching
  • Loss of appetite
  • Mood changes
  • Vertigo
  • Abnormal functions of thesensory nerves of the legs and arms causing numbness and tingling

Seriousside effects are:

  • Severe numbness of thelimbs
  • Seizure
  • Pain in the upper stomach,yellowing of the eye and skin
  • Severe vomiting
  • Light-headed feeling
  • Severe dizziness

If youwill experience other side effects not mentioned above, consult your doctorright away.

Important Information

  • Do not use this medicationif you have severe bone marrow suppression or severe nerve problems.
  • Altretamine can affectyour nervous system. In case of serious side effects like fainting, seizure andsevere dizziness, seek medical attention right away.
  • Do not use this medicationif you are allergic to it.
  • Inform your doctor if youhave recently used an MAO inhibitor and other medications.
  • Pregnant and breastfeedingwomen must not use this medication.
  • Your blood should betested more often because this medication can lower your blood cells that helpfight infections.
  • You may also have to checkyour muscle and nerve functions more often.