Levodopa is inactive by itself, but is the immediate precursor of transmitter dopamine. More than 95% of oral dose of Levodopa is decarboxylated in peripheral tissues and only 1-2% crosses brain. Levodopa is taken up by dopaminergic neurons and is converted to dopamine, which is stored and released as neurotransmitter. Carbidopa is an extracerebral dopa decarboxylase inhibitor. Carbidopa does not penetrate blood brain barrier and does not inhibit the conversion of levodopa to dopamine in brain. You can buy Levodopa here at Rx 2 Go Pharmacy and be assured of superior quality prescription drugs every time you buy from us.
The striatum of patients with Parkinsons disease is deficient in dopamine. Levodopa is a dopamine precursor and Carbidopa is peripheral decarboxylase inhibitor. The combination of Carbidopa-Levodopa increases the half-life of Levodopa in the periphery and makes more of Levodopa cross blood brain barrier and reaches the site of action.
The common side effects reported with Sinemet are chest pain, asthenia, cardiac irregularities, hypotension, orthostatic hypotension, hypertension, syncope, phlebitis, palpitation, dark saliva, gastrointestinal bleeding, duodenal ulcer, anorexia, vomiting, diarrhea, constipation, dyspepsia, dry mouth, taste alterations, agranulocytosis, anemia, thrombocytopenia, leukopenia, confusion, agitation, dizziness, somnolence, dream abnormalities, insomnia, paresthesia, headache, depression, dementia, pathological gambling and increased libido.
The concomitant administration of Sinemet and antihypertensive drugs or MAO inhibitors can cause orthostatic hypotension. The administration of Dopamine D2receptor antagonists and isoniazid with Levodopa can cause a loss in its efficacy and therapeutic response. Iron salts reduce the bioavailability of Sinemet. Sinemet should be used cautiously in patients with chronic wide-angle glaucoma. It is not advisable to consume Sinemet drug during pregnancy. Carbidopa -Levodopa should not be administered to nursing mothers and patients below age of 18.
Sinemet tablets are available in a 1:4 ratio of carbidopa to levodopa as well as 1:10 ratio. The recommended starting dose of Sinemet is one tablet 25-100 three times a daily.
The active ingredients are Carbidopa and Levodopa in both brand and generic forms because of which the mechanism of action and drug interactions are the same. The difference between brand and generic forms are packaging, pricing and the brand name. Generic variants are priced cheaper because there are no brand names associated with it as well as no expenses towards research and development. You can buy cheap Sinemet medicine when it is sold as a generic variant.
You can purchase Carbidopa Levodopa online from rx2go.com. When you order Sinemet drug online from us, it will reach your doorstep without any hassles. You can also be assured of superior quality generic drugs at the lowest prices when you buy Sinemet online from our online pharmacy.
At Rx 2 Go Pharmacy, we are continuously improvising on cost saving measures. Our expenses towards research and development are also practically nil. We source the prescription drugs directly from the manufacturers and enjoy price benefits on bulk ordering, all of which are passed on to our customers.
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