Clopidogrel is a prodrug that interferes with platelet function and is useful in the prophylaxis of thromboembolic disorders. Antiplatelet drugs like Clopidogrel are more useful in arterial thrombosis, while anticoagulants are more effective in venous thrombosis. Prostacyclin (PGI2) synthesized in intima of blood vessels is a strong inhibitor of platelet aggregation. The Platelet sticks to damaged vessel wall and releases ADP and thrombaxane A2 (TXA2). A balance between TXA2 and PGI2 control intravascular thrombus formation. Clopidogrel prolongs the bleeding time and increases the platelet survival in extracorpeal circulation. Generic variants of Plavix are also available now. You can buy Clopidogrel here at Rx 2 Go Pharmacy.
Clopidogrel causes sticking of platelets to the damaged vessel wall and it aggregates to form a platelet plug. The platelet plug releases ADP and thrombaxane A2 (TXA2). In veins due to the sluggish blood flow a fibrinous tail is formed that traps RBCs and in arteries the thrombus is due to platelet plug. Plavix alters the receptors on platelets and inhibits ADP and fibrinogen induced platelet aggregation. The purinergic receptors which mediate adenylyl cyclase inhibition by ADP are blocked by Clopidogrel. This prevents activation of platelets. Plavixl also prevents fibrinogen binding to platelets but does not affect TXA2.
The common side effects reported with Clopidogrel are chest pain, influenza like symptoms, pain, fatigue, edema, hypertension, head ache, dizziness, abdominal pain, dyspepsia, diarrhea, nausea, hypercholesterolemia, back pain , purpura, depression, upper respiratory tract infection, bronchitis, coughing and urinary tract infection.
The concomitant use of non-steroidal anti-inflammatory drugs (NSAIDs) and Plavix should be avoided as it can cause occult gastrointestinal blood loss. The co-administration of Plavix and warfarin should be done with caution, as there is a risk of increased bleeding. Plavix should be used with caution in patients with renal or hepatic impairment. Clopidogrel should not be administered to pregnant women. If it is an absolute must to take Plavix during pregnancy, it should be administered under the supervision of a medical practitioner. Clopidogrel should not be administered to nursing mothers and in pediatric patients. Plavix is contraindicated in patients with peptic ulcer or intracranial hemorrhage.
The recommended starting dosage of Plavix is 75 mg once daily. In non ST segment elevation acute coronary syndrome single loading dose of 300mg is given followed by 75mg once daily. In ST segment elevation acute coronary syndrome 75mg once daily is given.
The active ingredient is Clopidogrel in both brand and generic forms. The mechanism of action and effectiveness is same for both generic and brand forms. The difference between brand and generic forms are packaging, pricing and the brand name. You can buy cheap Plavix pills when it is sold as a generic variant.
You can purchase Plavix medicine online from our pharmacy. When you order Plavix drug online from us, it will reach your doorstep without any hassles. You can also save more when you buy Plavix online in more numbers with the volume discounts we offer.
At Rx 2 Go Pharmacy, we sell generic Plavix, which means that we do not have to spend heavily on research and development of the drug. We also source the drugs directly from the manufacturer thereby eliminating any additional costs such as commissions to agents etc. All the savings accrued through various measures translates to the cheaper price of prescription drugs at Rx 2 Go Pharmacy. You can also get additional price benefits by taking advantage of the volume discounts we offer.
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