Glipizide SR can be used as an alternative to insulin in patients who are having stable diabetes. Glucotrol XL causes insulin secretion at any glucose concentration. Glucotrol XL is used in patients whose diabetes cannot be controlled by diet and exercise alone. Glucotrol XL has good oral absorption. The insulin secretion from pancreas occurs in two phases. Glucotrol XL primarily augments the second phase of insulin secretion with little effect on the first one. Glipizide SR is highly bound to plasma proteins and has low volume of distribution. There are generic variants of Glipizide SR available, which are priced cheaper than the brand. You can buy Glipizide SR here at Rx 2 Go Pharmacy.
Glucotrol XL acts on sulfonyl urea receptor on pancreatic beta cell membrane. This causes depolarization by reducing the conductance of ATP sensitive potassium channels. This in turn increases the calcium influx and insulin release.
The common side effects reported with Glucotrol XL are asthenia, head ache, dizziness, nervousness, tremor, diarrhea, flatulence, pain, insomnia, anxiety, depression, nausea, dyspepsia, constipation, vomiting, hypoglycemia, leg cramps, syncope, sweating, pruritis, rhinitis, polyuria and blurred vision.
When sulfonyl ureas are replaced by Glipizide SR, the condition of the patient should be monitored carefully for 1-2 weeks. Glucotrol XL is not recommended in pregnancy, nursing mothers and in pediatric patients. Glucotrol XL can cause precipitate hypoglycemia when administered along with non-steroidal anti-inflammatory drugs (NSAIDs) and other highly protein bound drugs. Glipizide SR can cause hyperglycemia with corticosteroids, thyroid products and diuretics. The patients with renal or hepatic dysfunction and adrenal insufficiency are more vulnerable to hypoglycemic attacks of Glucotrol XL. In elderly and malnourished people the dose of Glucotrol XL should be selected carefully as they are more prone to hypoglycemia.
The recommended starting dosage of Glucotrol XL is 5mg daily administered with break fast. The maximum tolerated dose of Glucotrol XL is 20mg daily.
Brand and generic Glucotrol XL contains Glipizide as the active ingredient. The mechanism of action and effectiveness is same for both generic and brand forms. The difference between brand and generic forms are packaging, pricing and the brand name. The generic version is always cheaper in cost. You can buy cheap Glucotrol XL pills when it is sold as a generic variant.
You can purchase Glipizide SR medicine online from our pharmacy. When you order Glucotrol XL drug online from us, it will reach your doorstep without any hassles. You can also save more when you buy Glucotrol XL online in more numbers with the volume discounts we offer.
At Rx2go.com, we sell generic Glucotrol XL, which means that we do not have to spend heavily on research and development of the drug. We also source the drugs directly from the manufacturer thereby eliminating any additional costs such as commissions to agents etc. All the savings accrued through various measures translates to the cheaper price of generic prescription drugs at Rx 2 Go Pharmacy. You can also get additional price benefits by taking advantage of the volume discounts we offer.
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