Losartan is used to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. Losartan acts as antihypertensive by vasodilation and improving the blood flow to heart. Angiotensin converting enzyme (ACE) converts Angiotensin I to Angiotensin II. Angiotensin II has very short half-life and it is acted upon by aminopeptidase to form Angiotensin III, which stimulates aldosterone secretion. Hydrochlorothiazide causes a fall in blood pressure by decreasing the total peripheral resistance. Hydrochlorothiazides are mild hypertensives and they potentiate the action of other hypertensives and prevent the development of tolerance. Hydrochlorothiazide is more effective in elderly patients. Generic variants of Hyzaar are now easily available and you can buy Losartan online at Rx 2 Go Pharmacy.
Losartan is an Angiotensin II receptor antagonist that causes vasodilation and decrease blood volume that results in a fall in blood pressure. Angiotensin II receptor antagonist prevents the secretion of Aldosterone that decreases the blood volume. Hydrochlorothiazide diuretics act by inhibiting the Na+ -Cl- symport at the luminal membrane. Hydrochlorothiazide exchanges sodium with potassium ion. Hydrochlorothiazide causes diuresis, which reduces plasma and extracellular fluid (ECF) volume and decreases cardiac output.
The common side effects reported with Losartan- Hydrochlorothiazide are fever, chills, orthostatic hypotension, facial edema, flushing, hypertension, pruritis, dermatitis, sexual dysfunction, libido changed, diarrhea, gastroenteritis, flatulence, muscle cramp, stiffness, anxiety, nervousness, numbness, somnolence, cough, upper respiratory tract infections and transient blurred vision.
Hyzaar can be administered along with other hypertensive agents. Hyzaar is not prescribed for patients with severe renal and hepatic impairment. For patients with severe renal impairment loop diuretics are the drugs of choice. Losartan – Hydrochlorothiazidecan be taken without regard of food. In patients with volume depletion Hyzaar is recommended at very low dose as initial therapy. Hyzaar when given along with alcohol, narcotics or barbiturates can potentiate orthostatic hypotension. The dosage adjustment of anti diabetic drugs is required if given along with Hyzaar. Losartan-Hydrochlorothiazide when given along with corticosteroids can cause hypokalemia. Losartan when given with lithium salts can cause lithium toxicity as Losartan reduces lithium excretion. The concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and cycloxygenase (COX-2) inhibitors with Hyzaar can cause a decrease renal function.
The recommended starting dosage of Hyzaar is 50/12.5mg/day. The maximum dose given is 100/25mg once daily. The dose increment is to be done after a period of 1 to 2 weeks. In patients with volume depletion, the dose of Losartan is 25mg/day.
Brand and generic Hyzaar contains Losartan as the main active ingredient and hence there is no significant difference between the two. The mechanism of action and the effectiveness remain the same in both brand and generic Hyzaar. The difference between brand and generic forms are packaging, pricing and the brand name. You can buy cheap Hyzaar online when it is sold as a generic drug.
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