Losartan is used alone or in conjunction with other antihypertensive agents. Losartan is also used to treat kidney problems in diabetes mellitus. Cozaar is indicated for diabetic nephropathy with increased creatinine levels and proteinuria. Angiotensin converting enzyme (ACE) converts Angiotensin I to Angiotensin II. Angiotensin II is an octapeptide in plasma, which is obtained by a precursor plasma alpha globulin and is involved in electrolyte, blood volume and pressure homeostasis. Angiotensin II do not inhibit break down so do not produce persistent cough. The amount of rennin in plasma controls the Angiotensin II generation. Angiotensin II has very short half-life and is acted upon by aminopeptidase to form Angiotensin III, which stimulates aldosterone secretion. You can now easily buy Losartan at Rx 2 Go Pharmacy.
Cozaar is an Angiotensin II receptor antagonist. The most important action of Angiotensin II is vasoconstriction, which is resulted by increasing adrenaline or noradrenaline release and by increasing sympathetic outflow. Angiotensin II causes vasoconstriction and prevents the secretion of aldosterone. Aldosterone causes an increase in blood volume. Angiotensin II receptor antagonist decreases blood volume and cause vasodilation, which result in a fall in blood pressure.
The common side effects reported with Losartan are asthenia, fatigue, infection, influenza like symptoms, fever, diarrhea, dyspepsia, gastritis, diabetic neuropathy, diabetic vascular disease, hypoglycemia, hyperkalemia, weight gain, cough and urinary tract infection.
The dose of Losartan should be reduced in patients with hepatic impairment. Cozaar is not prescribed for patients with severe renal impairment. Cozaar when given with lithium can cause lithium toxicity. The concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and Cozaar can increase renal impairment. The patient should be advised to avoid potassium supplements during Cozaar treatment. Losartan is not recommended for pediatric patients below the age of 6. Avoid taking Cozaar during pregnancy and lactation.
The recommended starting dosage of Cozaar is 50mg once daily. In patients who are on diuretic treatment, the dosage of Losartan is 25mg/day. In pediatric patients of age more than 6, the recommended dosage is 0.7mg/kg/day.
Brand and generic Cozaar contains Losartin as the main active ingredient and hence there is no significant difference between the two. The mechanism of action and the effectiveness remain the same in both brand and generic Cozaar. The difference between brand and generic forms are packaging, pricing and the brand name. You can buy cheap Cozaar online when it is sold as a generic drug.
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