Metronidazole is a nitroimidazole, which acts as an ameobicide. Flagyl does not affect aerobic bacteria. Flagyl is selectively toxic to anerobic bacteria. Aerobic environment attenuates cytotoxicity of Metronidazole by inhibiting its reductive activation. Flagyl is widely distributed in the body, attaining therapeutic concentration in vaginal secretion, semen, saliva and CSF. Flagyl is used in the treatment of trichomoniasis and amebiasis. You can easily buy Metronidazole here at Rx 2 Go Pharmacy without any hassles.
The nitro group of Metronidazole is reduced by certain redox proteins operative only in anaerobic microbes to highly reactive nitro radical, which exerts cytotoxicity by damaging DNA and other biomolecules. Metronidazole causes DNA helix destabilization and strand breakage. Metronidazole has been found to inhibit cell mediated immunity, to induce mutagenesis and to cause radiosensitization.
The common side effects reported with Flagyl are furry tongue, glossitis, stomatitis, reversible neutropenia, reversible thrombocytopenia, convulsive seizures, peripheral neuropathy, dizziness, vertigo, incoordination, ataxia, confusion, irritability, depression, weakness, insomnia, urticaria, erythematous rash, flushing, nasal congestion, dryness of the mouth, fever, dysuria, cystitis, polyuria, incontinence, and a sense of pelvic pressure.
Metronidazole potentiates the anticoagulant effect of warfarin and other oral coumarin anticoagulants and increases prothrombin time. The concomitant administration of phenytoin or phenobarbital accelerates the elimination of metronidazole. The co administration of cimetidine and Flagyl prolongs the half-life and decreases plasma clearance of metronidazole. Flagyl can cause lithium toxicity. The patient should be advised to avoid alcohol during Metronidazole treatment as it can cause abdominal cramps, nausea, vomiting, headaches, and flushing. The dose of Metronidazole should be reduced in patients with hepatic disease. Flagyl is contraindicated during the first trimester of pregnancy. Nursing mothers should not use Flagyl.
The recommended dose of Metronidazole for the treatment of trichomoniasis is 2g given as a single dose or in two divided doses or 250 mg three times daily for seven consecutive days. The recommended dose of Metronidazole for the treatment of acute intestinal amebiasis is 750 mg orally three times daily for 5 to 10 days. The recommended dose of Metronidazole in pediatric patients is 35 to 50 mg/kg/24 hours, divided into three doses, orally for 10 days.
The active ingredient is Metronidazole in both brand and generic forms because of which the mechanism of action and drug interactions are the same. The difference between brand and generic forms are packaging, pricing and the brand name. Generic variants are priced cheaper because there are no brand names associated with it as well as no expenses towards research and development. You can buy cheap Flagyl medicine when it is sold as a generic variant.
You can purchase Flagyl medicine online from our pharmacy. When you order Flagyl drug online from us, it will reach your doorstep without any hassles. You can also save more when you buy Flagyl online in more numbers with the volume discounts we offer.
At Rx 2 Go Pharmacy we are always working out methods to save costs. Our costs towards research and development are zero, since we sell only generic drugs. We source the prescription drugs directly from the manufacturers and also order in bulk volume. All the savings from the various methods adopted translate to cheap prices of our drugs.
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