Pioglitazone is a thiazolinedione that enhances the transcription of insulin responsive genes. Pioglitazone improves the entry of glucose in to muscles and fats. Actos suppresses hepatic gluconeogenesis. Actos has glucose sensitizing action due to activation of genes that regulate fatty acid metabolism and lipogenesis in adipose tissue. Actos reduces blood glucose level without increasing circulating insulin. Actos is used to supplement sulfonyl ureas or metformin in type 2 diabetes mellitus or in case of insulin resistance. Pioglitazone can also be used as monotherapy along with diet and exercise in mild cases and to supplement insulin in advanced cases. Generic variants of Actos are no available at cheaper prices compared to the brand. You can buy Pioglitazone here at Rx 2 Go Pharmacy.
Pioglitazone is a selective agonist of peroxisome proliferator-activated factor γ (PPARγ). PPAR receptors are found in adipose tissue, skeletal muscle and liver. Pioglitazone reverse insulin resistance by stimulating GLUT4 expression and translocation.
The common side effects reported with Actos are upper respiratory tract infection, head ache, sinusitis, myalgia, tooth disorder, pharyngitis and may aggravate diabetes mellitus.
Pioglitazone can be given without regard of food. Pioglitazone when combined with other hypoglycemic agents or insulin can precipitate hypoglycemia. Pioglitazone should be used with caution in patients with edema as it causes fluid retention and progresses to congestive heart failure. It is advised to regularly check blood glucose and glycosylated hemoglobin levels when Actos is being administered. There is a probability of weight gain as a part of Actos therapy. Pioglitazone can cause ovulation in premenpausal anovulatory women.
The recommended starting dosage of Pioglitazone is 15 or 30mg once daily. The dose can be titrated to a maximum of 45mg once daily.
Brand and generic Actos contains Pioglitazone as the main active ingredient and hence there is no significant difference between the two. The mechanism of action and the effectiveness remain the same in both brand and generic Actos. The difference between brand and generic forms are packaging, pricing and the brand name. You can buy cheap Actos online when it is sold as a generic drug.
You can purchase Pioglitazone medicine online from our pharmacy. When you order Actos drug online from us, it will reach your doorstep without any hassles. You can also save more when you buy Actos online in more numbers with the volume discounts we offer.
At Rx 2 Go Pharmacy, we sell generic Actos, which means that we do not have to spend heavily on research and development of the drug. We also source the drugs directly from the manufacturer thereby eliminating any additional costs such as commissions to agents etc. All the savings accrued through various measures translates to the cheaper price of generic prescription drugs at Rx 2 Go Pharmacy. You can also get additional price benefits by taking advantage of the volume discounts we offer.
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