Pramipexole is used in advanced cases of Parkinsons disease as a supplementary drug to levodopa. Patients with minimum gastrointestinal side effects better tolerate Mirapex. Mirapex causes lower incidence of dyskinesias and motor fluctuations. Mirapex is now being used as monotherapy for early Parkinsons disease. Pramipexole treatment can provide longer symptom-free life to Parkinsons disease patients. You can easily buy Pramipexole online through Rx 2 Go Pharmacy.
Pramipexole is selective D2/D3 receptor agonist with negligible affinity for D1 and nondopaminergic receptors. The exact mechanism of action of Mirapex to treat Parkinsons disease is unknown. It is believed that the drug stimulates the dopamine receptors in the striatum, which is thought to be contributing to treating Parkinsons disease.
The common side effects reported with Mirapex are asthenia, general edema, malaise, fever, nausea, constipation, anorexia, dysphagia, peripheral edema, decreased weight, dizziness, somnolence, insomnia, hallucination, confusion, amnesia, hypesthesia, dystonia, akathisia, thinking abnormalities, decreased libido, vision abnormalities and impotence.
The dose of Pramipexole should be reduced and the period of the titration of dose should be increased in patients with renal impairment. Mirapex can exacerbate preexisting dyskinesia when given along with levodopa. Mirapex should be taken along with food to reduce nausea. It is not advisable to consume the Pramipexole drug during pregnancy. If it is an absolute must to take Pramipexole during pregnancy, it should be administered under the supervision of a medical practitioner. Nursing mothers should not use Pramipexole. The use of Pramipexole is contraindicated in children.
The recommended starting dosage of Mirapex for Parkinsons disease is 0.375 mg/day given in three divided doses. The dose of Mirapex should be increased only in a period of 5-7 days. The maximum dose of Mirapex is 4.5mg/day taken in three divided doses. The dose of Pramipexole in restless legs syndrome is 0.125 mg taken once daily 2-3 hours before bedtime.
The active ingredient is Pramipexole in both brand and generic forms because of which the mechanism of action and drug interactions are the same. The difference between brand and generic forms are packaging, pricing and the brand name. Generic variants are priced cheaper because there are no brand names associated with it as well as no expenses towards research and development. You can buy cheap Mirapex medicine when it is sold as a generic variant.
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