Sumatriptan dilates cranial extracerebral blood vessels during migraine attack and diverts the blood flow away from brain parenchyma. Sumig reduces inflammatory neuropeptide release around the affected blood vessels as well as extravastion of plasma proteins across dural vessels. Sumig suppresses neurogenic inflammation of cranial vessels and impulse transmission in the trigeminovascular system. You can now easily buy sumatriptan at Rx 2 Go Pharmacy without ant hassles.
Sumatriptan is an agonist for 5-HT1D/B. Sumatriptan has weak affinity for 5-HT1A, 5-HT5A, and 5-HT7 receptors and no pharmacological activity at 5-HT2, 5-HT3, or 5-HT4 receptor sub-types or at alpha1, alpha2, or beta-adrenergic; dopamine1; dopamine2; muscarinic; or benzodiazepine receptors. The activation of 5-HT1 is believed to relieve headaches associated with migraine.
The common side effects reported with Sumig are burning sensation, numbness, palpitations, syncope, decreased blood pressure, increased blood pressure sinusitis, tinnitus, allergic rhinitis, upper respiratory inflammation, external otitis, hearing loss, nasal inflammation, sensitivity to noise, diarrhea, myalgia, photophobia, dyspnea, sweating and hypersensitivity.
The concomitant use of MAO inhibitors and Sumatriptan is not recommended. The dose of Sumig should be low in case the patient is suffering from hepatic or renal impairment. The co-administration of Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors can cause serious Serotonin Syndrome. The use of ergot-type medications and Sumatriptan within 24 hours of each other should be avoided as it can cause vasospastic reactions. Sumig can cause chest discomfort and jaw or neck tightness. The prolonged use of Sumig can cause toxicity in melanin rich tissues. Sumatriptan should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Sumatriptan gets excreted in to breast milk. Avoiding breastfeeding for 12 hours after treatment with Sumatriptan can minimize infant exposure to Sumatriptan. Sumatriptan should not be given to pediatric patients. The use of Sumig is contraindicated in patients with uncontrolled hypertension, ischemic cardiac, cerebrovascular, or peripheral vascular syndromes. Sumig should not be administered to patients with hemiplegic or basilar migraine.
The recommended dosage of Sumatriptan for the acute treatment of migraine in adults is single doses of 25, 50, or 100 mg. The dose can be repeated after 2 hours if sufficient clinical response is not seen in patients. The maximum tolerated dose of Sumatriptan is 200mg/day.
The active ingredient is Sumatriptan in both brand and generic forms because of which the mechanism of action and drug interactions are the same. The difference between brand and generic forms are packaging, pricing and the brand name. Generic variants are priced cheaper because there are no brand names associated with it as well as no expenses towards research and development. You can purchase cheap Sumig medicine when it is sold as a generic variant.
You can purchase Sumig medicine online from our pharmacy. When you order Sumig drug online from us, it will reach your doorstep without any hassles. You can also save more when you buy Sumatriptan online in more numbers with the volume discounts we offer.
At Rx 2 Go Pharmacy, we believe in providing the best drugs at the cheapest prices. To meet this objective, we are continuously working out methods to reduce the cost. Some of the initiatives taken are direct sourcing from manufacturer and bulk ordering. All cost savings accrued translate to cheaper prices of our prescription drugs and medications.
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