Sulfamethoxazole and Trimethoprim is an intermediate acing sulfonamide. The oral absorption of Sulfamethoxazole is slow. Sulfamethoxazole is the preferred compound for combining with Trimethoprim as both have similar half-life. Trimethoprim is a diaminopyrimidine. The fixed dose combination of Sulfamethoxazole and Trimethoprim is known as Cotrimoxazole. Sulfamethoxazole and Trimethoprim are bacteriostatic individually and become bactericidal when combined together. Trimethoprim has larger volume of distribution and attains lower plasma concentrations. Hence an optimum synergy is exhibited at a concentration ratio of Sulfamethoxazole 20: Trimethoprim 1. Trimethoprim enters blood brain barrier and placenta. You can buy Trimethoprim Sulfamethoxazole here at Rx 2 Go Pharmacy and use this combination drug to fight off several bacterial infections.
Timethoprim Sulfamethoxazole inhibits the conversion of para amino benzoic acid (PABA) to dihydrofolate (DHFA) by inhibiting folate synthetase enzyme. Trimethoprim inhibits bacterial dihydrofolate reductase and blocks the conversion of dihydrofolate (DHFA) to tetra hydro folate (THFA). Thus Bactrim causes a sequential block of folate metabolism in bacteria.
The common side effects reported with Bactrim are nausea, vomiting, anorexia, rash and urticaria, agranulocytosis, aplastic anemia, thrombocytopenia, hepatitis, elevation of serum transaminase and bilirubin, renal failure, interstitial nephritis, toxic nephrosis with oliguria and anuria, hyperkalemia, convulsions, peripheral neuritis, cough, shortness of breath and pulmonary infiltrates, weakness, fatigue and insomnia.
Bactrim is not recommended in infants below the age of 2 months. Bactrim should be used with caution in patients who are taking thiazide diuretics as it can increase the incidence of thrombocytopenia with purpura. The combination of Sulfamethoxazole and Trimethoprim should be used carefully along with anticoagulant warfarin as it can prolong the prothrombin time. The serum digoxin levels should be monitored when given along with Bactrim. Bactrim should be given with caution in patients with renal or hepatic dysfunction, folate deficiency or bronchial asthma. Bactrim potentiates the effect of oral hypoglycemics in diabetic patients. Bactrim should not be administered in pregnant woman and nursing mothers as sulfamethoxazole and trimethoprim interfere with folic acid metabolism.
The recommended starting dosage of Bactrim in adults for urinary tract infection and acute exacerbations of chronic bronchitis is 2 Bactrim tablets every 12 hours for 10 to 14 days. The recommended dose for children with urinary tract infections is 40 mg/kg sulfamethoxazole and 8 mg/kg trimethoprim given in two divided doses every 12 hours for 10 days. The recommended dosage for patients Pneumocystis carinii pneumonia is 75 to 100 mg/kg sulfamethoxazole and 15 to 20 mg/kg trimethoprim given in equally divided doses every 6 hours for 14 to 21 days. The recommended dose of Bactrim in travellers diarrhea is 2 Bactrim tablets every 12 hours for 5 days.
The active ingredients are Sulfamethoxazole and Trimethoprim in both brand and generic forms. Therefore the drug interactions and mechanism of action remains the same. The difference between brand and generic forms are packaging, pricing and the brand name. In comparison to brand form generic version is cheaper in cost. You can buy cheap Bactrim pills when it is sold as a generic variant.
You can purchase Trimethoprim medicine online from our pharmacy. When you order Bactrim drug online from us, it will reach your doorstep without any hassles. You can also save more when you buy Bactrim online in more numbers with the volume discounts we offer.
Being a generic drug, there are no costs involved in research and development activities. We also source the drugs directly from approved manufacturers. Buying in bulk helps us in getting volume discounts. All these savings translate as cheaper price of Prescription Drugs at Rx 2 Go Pharmacy.
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