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Sildenafil Professional: Sildenafil + Dapoxetine To Treat ED

It is newly formulated advanced medicine. Sildenafil treats the erectile dysfunction in adult men. Dapoxetine helps to fight premature discharge of sperm (also called premature ejaculation). Combination of these ensures a sensual and long lasting sexual encounter. It is a unique combination which provide double benefits. It is advance form of the famous Viagra. It is more useful as compared to plain Viagra. It includes same performance with decreased time limit. Take it 15-20 minutes prior to sexual intercourse.

HISTORY:

In 1996 Classic Viagra was first time introduced in the market. It was initially invented for high blood pressure. On further studies, it turned to be a wonder pill for male impotence treatment. So, they quickly remarket it for male impotence. Finally, in 1998 it was accepted by FDA to treat ED.

WORKING:

The mechanism of Viagra professional is same as Viagra. The same active ingredient Sildenafil makes all the magic. The difference is its strength.  It is double as compared to regular Viagra. The drug enters the blood and relaxes the muscle. It prevents the work of PDE-5 in the body. It widen arteries and increase flood to the penis. The erection takes place and maintains for a longer time.

Sildenafil & Dapoxetine

 

DOSAGES OF SILDENAFIL PROFESSIONAL:

It is available in two strengths

  1. (i) 50 mg
  2. (ii) 100 mg

Take 1 pill one time a day. Take it 30 min previous to the sexual intercourse. Take it with a glass of water or any other liquid. Avoid grape fruit juice. Initial starting dose is 50 mg. Doctor increases the dose to 100 mg if one doesn’t achieve a significant result. It is a type of scheduled dose. Take a single capsule 30 minutes before sexual intercourse.

ADVANTAGES OF SIDENAFIL PROFESSIONAL:

Single tablet of Sildenafil + Dapoxetine contain double dose.

This reduces the in between time period to 15-20 minutes.

  1. Its effects last for up to 8 hours
  2. It maximized increased penis erection
  3. Improved control time. Triggers penis expansion and hardness for excellent performance.
  4. It’s cost is much cheaper than classic Viagra
  5. It contains additional secondary component. This reduce number of negative result.
  6. It treats high blood pressure. In combination with other drugs it can be very efficient.
  7. It is useful in sports, recreational use, and jet lag research. But direct evidences are still lacking.

SIDE EFFECTS OF SIDENAFIL PROFESSIONAL:

We know that Sildenafil professional show benefits over Viagra classic. It shows decreased amount of side effects among the users . It show fewer side effects and many benefits in comparison. Some adverse effects shown by Sildenafil prof are as follows;

  1. Nausea
  2. Muscle ache
  3. Constipation
  4. Weakness
  5. Headache
  6. Diarrhea
  7. Nasal congestion

Cases with serious effect in case of this pills is rare like;

In patient age 40 years and above, they may face temporary loss of hearing

They may raise the level of blood pressure. Patient taking nitrate medicine should take caution , as this pill can render  the blood pressure low.

In such cases contact your doctor.

INTERACTIONS:

  • Other sildenafil products
  • Other ED treatment medicine
  • Nitrates etc.

PRECAUTIONS:

  1. Avoid alcohol consumption while taking this pill
  2. Avoid high fat food
  3. Avoid drinking grape fruit juice
  4. It is necessary to take precaution in certain cases like;
  5. History of stroke
  6. People with history of heart failure, heart attacks etc.
  7. People suffering from uncontrolled blood pressure
  8. Those who show allergy to Sildenafil
  9. People should avoid fatty substance and drinking alcohol. This would increase the efficacy of the pill

Dapoxetine 60mg (LONG DRIVE - 60)

COST OF GENERIC DRUG vs THE BRAND:

The difference between brand and generic drug is quite considerable. The brand names are protected by the trade name. Pharma companies that hold patent produce them. These brands are much costlier than generic. Both the brand and the generic contain the same active ingredient.

E.g. Cost of generic sildenafil + dapoxetine is $1.20 which is little compared to  the brand Viagra.

From the above discussion, it is clear that Sildenafil Professional  is both  efficient  and will give you satisfaction (to you and your partner that is).

Valacyclovir Herpes Zoster and Herpes B

Valacyclovir is a generic drug available in market with brand names Valtrex and Zelitrex.

  • It is an antiviral drug.
  • It helps to treat Herpes simplex, herpes zoster (shingles), and herpes B.
  • It is helpful in treating infection caused by herpes virus including genital herpes and cold sores.

HISTORY:

Burroughs welcome Co. (at present GSK) developed several water soluble ester of acyclovir. One of them was the above described drug. They patented the invention of this drug in 1988.It is at present marketed by Glaxo Smith Kline (GSK). They sold it under brand names Valtrex and Zelitrex. It is available as generic drug in US since November 25, 2009. It was first discovered in 1988 in USA

Herpes zoster (shingles)                                                    – June 1995

Recurrent genital herpes                                                   – December 1995

Initial infection of genital herpes                                     – October 1996

Suppressive therapy for genital herpes                           – September 1997

Cold sores (Herpes labialis)                                              – September 2002

Centrex 500

MECHANISM OF ACTION:

Valacyclovir is a prodrug. That means it isn’t active itself. It converts into acyclovir in the body. It is active against viruses. It help to avoid the replication of viral DNA. This is necessary for viral DNA to multiply. This stops the spread of virus in the body. So the above drug is active against the same viruses as acyclovir. But it show advantages due to longer duration of action. Due to this advantage the number of pill per day reduces.

DOSAGES:

Valacyclovir is available in 500 and 1000 mg tablet. It is an oral medicine. Take it with or without food. Drinking plenty of water reduce the chances and the strength of side effects. Dosage is dependent on the type of infection and medical condition. For chicken pox in children amount of drug is as per weight of child. For shingles it is necessary to start medicine as the rashes appear. Keep the amount medicine at a constant level to see best effects. Avoid changing, skipping or stopping your dose till the course complete. This will ensure the effect of the drug.

ADVANTAGES:

  1. It treats infection caused by certain types of virus.
  2. In children, it treats cold sores near the mouth caused by herpes simplex
  3. It help to cure chickenpox caused by zoster
  4. In adults it treats shingles and cold sores near the mouth
  5. Helps to treat outbreak of genital herpes
  6. It reduces the number of future out breaks
  7. It decreases the severity out break
  8. It helps to heal the sores
  9. Decreases the pain and itching

 SIDE EFFECTS:

Some of the common side effects observe are as follows;

  1. Vomiting
  2. Nausea
  3. Headache
  4. Increased liver enzymes
  5. Abdominal pain
  6. Cold symptoms

Above symptoms are temporary. They appear for short period. They disappear as body become used to the medicine. Other serious side effects are as discussed below;

  1. Central nerves problems
  2. Agitation
  3. Increased heart rate
  4. Confusion
  5. Depression
  6. Some brain disorder

These are rare cases. But it is important to take doctor advice.

PRECAUTIONS:

  • Reduced dosage for kidney patients
  • No adequate evidence present to show its safety in pregnant or breast feeding women. Use it if benefit to the mother outweighs risk to the fetus
  • Safety and efficiency isn’t proved in patients

< 12 years of age with cold sores

< 2 years of age or > than 18 years of age with chickenpox

< 18 years of age with genital herpes

< 18 years of age with herpes zoster

  • Counseling for safe sex practices
  • Adequate hydration

Valacyclovir

COST OF VALACYCLOVIR VERSUS BRAND VELTREX:

The generic version is cheaper than brand ones. They show same effect as brand version. They vary in case of cost. The cost of generic version is low i.e.; $ 0.91 for per pill of 500 mg tablet and $ 1.22 for per pill of 1000 mg tablet. The brand Valtrex by canDrugstore.com is as high as $ 5.40 for per pill of 500 mg tablet. Online drugs sells 1000 mg per pill for $9.92.

Celecoxib Treats Different Types of Pain and Inflammation

Celecoxib is a generic drug sold under the brand name Celebrex. It is a pain medicine. It treats different types of pain and inflammation. It reduces pain in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It is effective in painful menstruation, pain in adults. It is helpful in juvenile arthritis in people two years or older. It belongs to class of NSAID drugs and sub group COX-2 inhibitors.

CREDIBILITY:

It treats arthritis and is marketed by Pfizer. It is sold only by prescription in the form of capsule. It was one of the best-selling drug by 2012. As of 2015, the cost for a typical month of medication in US was more than $200. As of 2017, the cost of generic version of Celecoxib was nearly $30. It is in market for over 17 years. Celebrex is approved by FDA. Teva pharmaceutical industries got the permission from FDA to market cheaper generic version of celecoxib capsule in 50, 100, 200, 400 mg On Friday, May 30 2014 ( so the generic is relatively new )

WORKING:

It gives relief from pain and discomfort due to various disease as described above. During inflammation body make prostaglandin that may cause pain. Celecoxib decreases the production of prostaglandin. This reduces the body pain. Thus giving  relief from pain and swelling.

Celecoxib 200mg

DOSAGES:

It is available in capsule form in the following strength 50 mg, 100 mg, 200 mg, and 400 mg.

It is to swallow along with water or any other liquid. Take it with food to avoid an upset stomach.  Standard dose is as follows;

  1. 100 mg – two times every day
  2. 200 mg – one time every day
  3. 400 mg – as a single dose on the first day and 200 mg two times on the following days. Take it at least five days. Available only on doctor’s prescription.

ADVANTAGES:

  1. It is useful for relieving pain in osteoarthritis, rheumatoid arthritis.
  2. It is effective in case of acute pain in adult musculoskeletal pain.
  3. Shows good result in ankylosing spondylitis and juvenile arthritis on people two years or older.
  4. It is effective same as ibuprofen in case of pain after surgery.
  5. Action is similar to paracetamol
  6. It is considered as first line treatment in osteoarthritis
  7. Evidences indicate its use in treating a number of psychiatric disorders.
  8. It gives comfort in other short term pain and menstruation cramps.

SIDE EFFECTS:

Common side effects include;

  1. Nausea
  2. Diarrhea
  3. Stomach upset
  4. Abdominal pain
  5. Headache
  6. Dizziness
  7. Nervousness
  8. Skin rashes
  9. Stuff nose
  10. Some other major side effects may be stomach and intestinal ulcer
  11. Chest pain, shortness of breath,
  12. Slurred speech,
  13. Loss appetite,
  14. Dark urine,
  15. Jaundice,

But these are rare cases .Call doctor if such major side effects occur.

PRECAUTIONS:

It is necessary to take precaution in certain cases as discussed below

  1. It belong to class of NSAID drugs. It can increase your risk of heart attack or other heart disease.
  2. Patients with heart surgery should not use it.
  3. If you are 65+ you may be at a risk of stomach bleeding, ulcer in the lining of stomach or intestine
  4. Avoid taking it if you are an asthmatic patient.
  5. Do not take in late pregnancy and during breast feeding
  6. Check if patient takes any other NSAID drugs as it can interact with them

Celecoxib (COBIX-200)

Cost of Celecoxib VS Celebrex:

Generic drugs are cheaper than brand named drugs and have the  same effect. They both contain the same active ingredient. Celebrex is costly because it’s a  brand name and was not available as generic form until 2014. It used to cost about $100 to $500 per month. Each pill cost $ 2. Single pill by Cheap drugs in Canada cost $3.30. Quality prescription drugs in USA cost $1.75. While the cost of generic Celecoxib is just $ 0.22 per pill. One can see the gargantuan difference in price – its sky high.

The above information clearly shows how effective is generic Celecoxib as compared to Celebrex . It is as effective and much …much more affordable.

6 Uses of Dapoxetine: Side Effects + Precautions

Dapoxetine is the first compound developed for the treatment of premature ejaculation in men. It is useful for age group of 18 to 64 years. Brand name for it is Prilligy. It can also be used as an  anti-depressant ,  but the body absorbs and eliminates it too quickly . Due to this it is better suitable for treatment of premature ejaculation . Premature ejaculation is a major issue in male sexual health. It is a common sexual dysfunction shared by many men.

Sildenafil & Dapoxetine

HISTORY OF DAPOXETINE:

Eli Lilly pharmaceuticals was the first company to create Dapoxetine. It was handed over to Johnson & Johnson in 2003. They submitted it as a new drug application to FDA for the treatment of PE in 2004. Menarini got the right in 2012, for  commercial basis in Africa and Asia .Later in  Latin America and the Middle East too.

WORKING OF DAPOXETINE:

Dapoxetine working is unclear. It is short acting selective serotonin inhibitor (SSRI). Serotonin is a chemical found in human body. It is present in the brain, bowels and blood platelets. It carries signal along and between the nerves. According to some scientist, it is useful for maintaining mood balance. Evidence shows that Dapoxetine  increase the discharge of semen latency time. Patient experience clear outcomes. Showing greater control over discharge of semen. It is ideal for on demand dosing. It is first and only licensed drug to treat PE in men aged 18 to 64 years.

6 USES OF DAPOXETINE:

  1. It is an anti-depressant
  2. It is useful in treatment of PE in men.
  3. Increases the activity of serotonin in the Nervous system
  4. It improve increase time to release of semen in the interior of vagina.
  5. They provide sexual satisfaction in patients
  6. Decreased adverse effects as compared to other medicines.

DOSAGES OF DAPOXETINE:

  1. It comes in two forms -30 mg or 60 mg tablets.
  2. Start with 30 mg tablet and can raise to 60 mg if needed.
  3. Take it 1 to 3 hours prior to sexual activity
  4. Don’t break or chew the pill. Swallow it with water.
  5. Take maximum of one pill in a day.
  6. The safe and efficacy is unexplained for men 65 and above.

COMMON SIDE EFFECTS OF DAPOXETINE:

It will show withdrawal symptoms if stopped at once. So it is necessary to decrease the dose slowly. Many side effects given below decreases with continued treatment. It does not need any cessation of therapy.

  1. Nausea
  2. Dizziness
  3. Headache
  4. Diarrhea
  5. Fatigue
  6. Insomnia
  7. Sedation

If one continues for long term use, its efficacy on the body decreases.

Other side effects that require counseling are as follows;

  1. AV block or sick syndrome
  2. History of severe depression
  3. History of syncope
  4. Sensitive to active ingredient

PRECAUTIONS BEFORE TAKING DAPOXETINE:

It is necessary to take care in certain conditions as discussed below

  1. It isn’t advised for patient with severe renal impairment
  2. In Hepatic impairment
  3. Inform your doctor regarding current medicine you take

Sildenafil & Dapoxetine-100mg-60mg

COSTS OF DAPOXETINE VS PRILLIGY:

Generic drugs are cheaper and as effective as their brand named counterpart . They both contain the same active ingredient. We can see a vast difference in their charges. For example generic Dapoxetine 60 mg costs $ 3.82 per pill. And the cost of brand Priligy manufactured in USA will cost you  up to  $ 42.67 per pill.

So it is important to consider the generic medicines. You will get the full beneficial effects at a cheaper price. In case, you decide to purchase Dapoxetine just Click Here.

5 Uses of Tadalafil the Generic Name of Cialis

Tadalafil is the  generic drug marketed under the brand name of  Cialis. It belongs to the class of PDE-5 inhibitor. Tadalafil treats erectile dysfunction (ED) in men.

Erectile dysfunction:  It is an oral drug which treats impotence in men. Impotence is an inability to attain or maintain a penile erection. It is one of the most common problem faced by men at a particular age or in old age. This disturbs his sexual life , therefore his happiness.

BPH:  It is another name for enlarged prostate gland. In this the prostate gland in men increase in size. It can create problems for the flow of urine due to the pressure on the  urethra. It can cause urine to go back in the bladder. This may lead to infection in the kidney.

Tadalafil-Sublingual-20mg

HISTORY:

There was great commercial market for Viagra (sildenafil) and Levitra (verdenafil) for the same reason discussed above. They got FDA approval. Their sales exceeded U.S $ 10 billion. This encouraged the discovery and approval of tadalafil on November 21, 2003.

A partnership between Glaxo and ICOS discovered the Tadalafil drug. In May 2002, Lilly ICOS informed the American Urologist Association. They said that clinical trial testing confirmed that it was effective for up to  36 hours. It got the FDA approval in 2003. In October 6, 2011 it even got approval from FDA as drug for the treatment of BPH (this is not the case for any other ED pills )

DOSAGE:

It is available in the form of 20mg, 40 mg, and 60 mg strength tablets. Take it with or without food, swallow it as a whole. For ED take it prior to sexual activity.  take one in every 1 ½ days.

WORKING:

ED: During sexual arousal, blood fills the blood vessels in the penis. This causes the penis erection. The blood vessels bring maximum blood to penis and fills it with blood. At the same time the blood vessels which take away decreases in size. So small amount of blood is remove from penis. The enzyme cGMP is responsible for the increase and decrease in size of blood vessels. It helps to return penis to its normal position too, when erection ends. Another enzyme PDE-5 destroys enzyme cGMP. This leads the Blood vessels to returns to normal size.  Blood leaves penis and ends the erection of the penis. Tadalafil prevents enzyme PDE-5 from destroying enzyme cGMP. This allows it to stay erect for longer. The penis remains full of blood for longer time leading to increase sexual activity .

BPH:  The working of Tadalafil in case of BPH isn’t clear. PDE-5 is present in the muscle of the bladder and the prostate. Scientist believe that increase and decrease in size of muscles due to tadalafil.

5 USES OF TADALAFIL (CIALIS):

  1. It shows good result in case of ED and BPH symptoms.
  2. It relaxes the muscles of blood vessels
  3. Increases the blood flow to penis and prostate gland areas. It works along with sexual stimulation.
  4. Advised for some treatments apart from medication guide .e.g. the treatment of pulmonary hyper-tension treatment.
  5. Its effect last for 36 to 48 hours.

5 COMMON SIDE EFFECTS OF TADALAFIL (CIALIS):

Common side effects which can be experience are;

  1. Dizziness
  2. Nausea
  3. Numbness
  4. Tingling or pain in the jaw, chest or neck
  5. Along with nitrate medication, it can cause drop in blood pressure

Tadalafil-Chew-20mg

7 PRECAUTIONS BEFORE TAKING TADALAFIL (CIALIS):

People with the following condition shouldn’t take Tadalafil unless a physician agrees

  1. Sickle cell anemia
  2. Leukemia or another blood cell disorder
  3. People with kidney or liver disease
  4. People who have stomach ulcer
  5. People with heart rhythm problems and other heart disease
  6. Those for health reason, doctors ask them to avoid sex
  7. People who have some kind of structural deformities in the penis.

COST OF GENERIC TADALAFIL VERSUS THE BRAND CIALIS

One can observe a huge difference between generic Tadalafil and brand Cialis. They both contain the same active ingredient and  shows the same effect. But it is the cost that matters 20 mg tablet for generic drug costs $0.81 which is negligible. The cost for brand version of Tadalafil (Cialis) costs $65.61 per pill. Therefore for the same results you may pay less then 1/60 of the price – there is truly no other difference between the brand and the generic drug aside from price.

Treating Major Depressive Disorder with Duloxetine

Duloxetine is a medicine to treat major depressive disorder. It helps to cure anxiety disorder, nerve pain in case of diabetes patients. It even gives relieve in fibro-myalgia. Duloxetine belongs to the class of SNRI drugs for treating depression and other disorders. It is helpful in arthritis and chronic back pain.

Duloxetine 20mg (DLX-20)

HISTORY:

Lilly researchers discover Duloxetine. Four persons including the co-discoverer of fluoxetine were inventors on the patent application. They filled it in 1986 and was granted in 1990. In 2001, Lilly filled a new drug application for this drug with the USA FDA. It got approval for various disease – see the step by step below;

YEAR                                                 APPROVAL

Aug 4, 2004                             For the treatment of depression

Sep 7, 2004                              For the treatment of generalized anxiety disorder

Feb 26, 2007                            For the treatment of nerve pain related to diabetes

Nov 30, 2007                           For the treatment of major depressive disorder

Jun 16, 2008                            To manage fibro-myalgia

Nov 3, 2009                             Treatment for maintenance of anxiety disorder

Nov 5, 2010                              For the treatment of chronic muscles and skeleton pain

As you can see it got  approval for various disease slowly over the years.

DOSAGES:

It is available in the form of tablets. The strength are 20 mg, 30 mg, 40 mg, and 60 mg. The Maximum dose is 120 mg per day.  Dosage depends upon the disease and its intensity. This varies from person to person. Increase in dose is step by step as required by patient.

Don’t chew, crush or open tablet. Swallow it as whole with water or other liquid. Take it with or without food.

USES:

  • It improves mood and sleep
  • improves appetite and energy level
  • Decreases nervousness
  • Decreases the pain due to certain medical condition like
  1. Fibro-myalgia
  2. Chronic back pain
  3. Osteo-arthritis
  4. Stress urinary incontinence
  5. Major depressive disorder
  6. Nerve pain in diabetic patients
  • It belongs to the class of SNRI drugs. This helps to restore the balance of certain natural substances in the brain
  • It is helpful in treating some disease out of the medication guide

SIDE EFFECTS:

It can show withdrawal effects such as;

  • Dizziness, Nausea
  • Fatigue, Vomiting
  • Insomnia, Diarrhea,
  • Anxiety etc.
  • It is necessary to reduce dose step by step over at least 2 weeks

Major Side Effects

In rare cases it can lead to major side effects .It is necessary to look for doctors if any of the following symptoms occur.

  • Stomach pain
  • Blurred vision
  • Change in alertness
  • Clay colored stools
  • Confusions
  • Faintness on getting up with speed from a lying or sitting position.
  • Irregular heart beat
  • Joint or muscular pain
  • Tightness in chest

PRECAUTIONS:

  • It is important to take special care to give the treatment in certain cases like;
  • Person with kidney or liver disease
  • Person with peritoneal or hemo-dialysis
  • Safety is unknown in patients younger than 18 years
  • It has got approval to use in patients aged 7-17 years in case of generalized anxiety disorder.
  • Don’t sprinkle capsule in food
  • Don’t drive or operate dangerous machinery

Duloxetine 20mg (DLX-20)

COST OF BRAND VERSUS GENERIC DRUG:

Generic drugs have same active ingredient as in brand drugs. It is a lower version of a brand drug. They vary in terms of packaging and pricing. The cost is 30- 80% low than brand drugs. Cost of 60 mg tablet of generic duloxetine cost $1.11. Cost of brand Cymbalta is $17 to $30 USD . There is a great difference in cost yet the generic and brand have the exact same effect on health – just not on the wallet .

The Pain Reliever Medicine Known As Tramadol

Tramadol is a type of pain relieving medicine.

  • It relieves moderate to severe pain.
  • After surgery this reduce pain.
  • It is a type short term medicine.
  • It changes the way Central Nervous system respond to pain.
  • It works in way your body feels and responds to pain.

ACTION:

Tramadol has two different reaction in the body. It is pain reliever and fever reducer. It changes the way your brain realize pain.

Rx 2 Go Pharmacy

 

USES:

  1. Tramadol is effective pain killer.
  2. Used as pain reliever post-surgery in human.
  3. Useful in depression.
  4. Effective in pain related to cancer and arthritis.
  5. Used post-surgery to reduce pain in cats and dogs.
  6. Given as cough suppressant in pets.

SIDE EFFECTS:

  • Causes withdrawal symptoms like restlessness, watering eyes, runny nose.
  • Other side effects like nausea and sweating.
  • Sometimes creates addiction.
  • Causes drowsiness and slow breathing along with alcohol and other drugs.
  • Can face seizure attack due to overdose.
  • Patient may experience vomiting and dry mouth.
  • Pain in joints and muscle.

DISADVANTAGES:

  1. Avoid long term use of medicine due to its side effects.
  2. Long term use decreases the effect if drug.
  3. Unable to overcome severe pain alone
  4. Large dose can lead to seizure attack or even death.
  5. People with history of kidney or liver problem should be alert to use it.

DOSAGES:

Generally doctor gives 1 to 2 – 50 mg tablet. It is available both in tablet and suspension. Dosage depends on patient and his needs. It is necessary to take small doses for short period. Take it as instruction given by doctor. Long term use is risky.

  • Long acting (tablet & capsule)-one in a day.
  • Regular -every 4 to 6 hours as needed.

Tramadol

PRECAUTIONS:

It is important to observe safety in certain cases like,

  • Patient with drug or alcohol abuse.
  • People having history of seizure.
  • Those who take medicine for depression or other narcotics.
  • People with kidney and liver diseases.
  • Children under 16 years of age.

Tramadol is safer as compared to other pain killers. But precaution is necessary as it shows many side effects. Over dose and long term use of Tramadol can cause harmful side effects. Can even lead to death.

Amoxicilin: First Choice Treatment For Bacterial Infections

Amoxicilin 250mg

Amoxicilin is a generic drug marketed under several brand names such as Amoxil, Amoxicot, Moxilin, Trimox etc.

  1. It is a penicillin antibiotic.
  2. It treats infections caused by a wide range of bacteria.
  3. It is the first choice for the treatment of middle ear infection.
  4. It is one of the oldest antibiotic in world.
  5. It is available in two types’ biotic agents and semi synthetic agents.
  6. It is effective on a wide range of bacterial infection.
  7. It is effective in case of bacterial and doesn’t work for viral infections.

HISTORY:

It is one of the several derivatives of 6-APAIt. FDA approved in 1960 at  Beecham research lab. It is sell in market by Glaxo Smith Kline in the brand name Amoxil and many others. The narrow spectrum of penicillin lead to search the derivative of penicillin. Ait was necessary to treat a wider range of infection. This lead to the research foe ampicillin had a broader spectrum of activity. Doctors were able to treat broader range of gram- positive and gram-negative infections

Further research lead to the development of the drug with improved action time. It shows a little structural difference between the two. The drug is lipid soluble. This allows it to kill bacterial little faster.

WORKING:

The cell wall is important for the survival of the bacterial. It is protective layer of cell. Above drug is penicillin antibiotic. It treats infection due to bacteria and helps bacteria to eliminate themselves from the body. They impair the bonds that hold the cell wall. This weakens the cell wall. Further it stops formation of cell wall in bacterial cell. This unable them to grow. This kills bacteria and helps curing infection.

Amoxicilin 500mg

DOSAGE:

It is available in the strength of 500 mg. General dose as per instruction is 500 mg per day. Take it for 5 days to 10 days. Take it orally with or without food. It is necessary to complete the dose though the symptom disappear. This assure complete treatment for bacterial infection. It avoids come back of bacterial infection. It is necessary to drink plenty of water to avoid side effects.

USES:

  1. It helps in treating infections as discussed below;
  2. Infection like acute bronchitis and pneumonia
  3. Nasal passage and throat
  4. Otitis-middle ear infection
  5. Kidney- urinary tract
  6. Infection of heart valves and heart lining

It is useful in treating disease which aren’t included in medication guide .They are as follows;

  1. Typhoid fever
  2. Lyme disease-starts with tick bite
  3. Peptic ulcer-stomach ulcer
  4. Dental procedures to prevent heart infection
  5. Chlamydial infection

PRECAUTIONS:

Contact your doctor or health care provider if any of the below given situations apply to you;

  • If you are allergic to medicines, food or other substances
  • If you have history of asthma or hay fever
  • If you are allergic to medicines food or other substances
  • If you have had a severe allergic reaction
  • Some medicines can interact with this drug. So tell your doctor of medicines you take any other medicine
  • If you are allergic to any ingredient in the above drug or another penicillin
  • It is necessary to take some other birth control measures it reduces the effect of birth control pill.

COST OF GENERIC VS. THE BRAND:

As discussed above it is available in many brand names. But than they are costlier as compared to the generic drugs. Cost of generic drug is $0.51 per pill. The cost of brand Amoxil is $1.45 per pill. This is a big difference. Both of them contain same active ingredient and shows same effect. So it is better to go for generic drugs.

Reboxetine Treatment For Depressive Disorders

Reboxetine is a generic drug sold as brand name Edronax. It belongs to the class of (NRIs). It is anti-depressant. WHO has ranked depression fourth in a list of urgent problems worldwide. Depression is a mental disorder. Patient remains in low mood for at least two weeks in this disorder. It include loss of interest, low energy, pain without a clear cause. Some people may hear or see things that don’t happen. It can effect a person life, sleeping, eating habits and general health. It is useful in panic disorder too.

HISTORY:

It is first published in 1984 discovered by farmitalia-caria Erba. It was hand over to Pharmacia in 1993. FDA accepted the approval in 1999. Pfizer in 2003 took charge of Pharmacia. But FDA issued “not approval” letter dependent on the clinical trials in 2001. In 2010, the British medical journal showed that it doesn’t work. The British MHRA in 2011 September said that each study had several limitation. Overall the balance of benefits and risk for above drug remains positive in its authorized indication.

WORKING:

It belongs to the class of NRIs drugs. It inhibits reuptake of noradrenaline. In depression, the amount of chemical (nor adrenaline) declines. The nerve cell in the brain releases this chemical .The chemical acts to lighten mood. Its amount decreases due to re-absorption in the nerve cell. This can affect mood. Above discussed drug works by preventing the re-absorption of this chemical back in the nerve cell. In this way it improves mood and relieve depression.

DOSAGE:

It is available in the form of tablets. Initial dose is 4 mg one or two times a day. Doctor can increase dose to 8 or 10 mg as needed. Maximum recommended dose is 12 mg per day.

USES:

  1. It is unique drug that deal with fear and stimulate the mind.
  2. It prevents the re-absorption of related chemical back in to the nerve cell. This improves the good mood.
  3. Majority of patients can tolerate it.
  4. Efficacy was in excess to the side effects.
  5. It helps restore social functioning and produce a better quality of remission.
  6. It acts as stimulant too.
  7. It is safer than SSRIs class of drugs.
  8. Some people take it as off label to treat low back pain.

 SIDE EFFECTS:

Some common side effects which don’t need medical attention. They reduce as the body gets use to it. They are as follows;

  • Headache
  • Dry mouth and increased sweating
  • Urinary hesitance
  • Stomach upset
  • Some rare cases include
  • Anxiety, loss of appetite
  • Loss of sexual desire
  • Urinary retention in men
  • Increased orgasm in men
  • Premature discharge of semen

PRECAUTIONS:

It is necessary to take care in certain conditions as discussed below;

  • It can interfere with other anti-depressant. It is necessary to take doctors advise to use it in combination.
  • Avoid driving. It reduces ability to drive or operate machinery
  • Don’t use in patients with severe heart problems, liver or kidney disease.
  • No evidence is present to prove the drug as safe in pregnancy and breast feeding.
  • Use of medicine isn’t allowed in children and adolescence under 18 years.

COST OF GENERIC VS BRAND VERSION:

In case of generic drug, it is available in 2 mg and 4 mg tablet. The cost of generic Reboxetine 2 mg is $ 0.28 and 4 mg is $ 0.38. However cost of brand version of drug sold in USA is $1.25 for 4 mg tablet. Here we can see the difference of price between the two.

 

Sumatriptan Treatment for Migraine & Cluster Headaches

Sumatriptan 50mg

Sumatriptan is a generic drug sold under brand names Imitrex, Imigran and treximet. It treats migraine and cluster headaches. Prompt treatment help one to return to normal routine. Migraine effects 1 in 8 person, in women and in the age of 30 to 50 years.

HISTORY                                                                                                                                     

Search for new anti-migraine drug started at Glaxo in 1972. In 1960 studies showed that constriction of vessel could reduce migraine attack. 5-HT drug showed many side effects. Scientist started to discover specific agonist for 5-HT receptors. AH25086 was a compound developed. It showed constriction of vessels. Though it wasn’t released due to low fraction of unchanged drug that reaches the systemic circulation. Studies lead to the discovery of the first triptan drug. Sumatriptan had both criteria. It was first launched in the Netherlands in 1991 and became available in USA in 1993.

MECHANISM

It is a medicine used in migraine and headache. It stimulates the 5-HT1B receptors on the smooth muscle cells of blood vessels. This narrows blood vessels all over the brain. It reduces the vascular inflammation due to migraine. It work by making those vessels normal by narrowing them. This reduces symptoms of migraine.

DOSAGES

It available in four types: 1. Oral, 2. Injection- under the skin, 3. Nasal spray, 4. Rectal. It is available in following strength.

  1. Oral tablets- 25 mg, 50 mg, 100 mg
  2. Injection- 4 mg/0.5 ml, 6 mg/0.5 ml, 3 mg/0.5 ml
  3. Other method-20 mg/ in h, 5 mg/ in h, 6.5 mg/ 4 hr

The subcutaneous route provide best relief from pain. If case of no effect or no improvement, give a second dose. Difference between two doses should be 2 hour. Maximum recommended dose is 200 mg.

Sumatriptan

ADVANTAGES

  • It is useful to treat migraine
  • It relieves headache
  • It helps reduces pain
  • It treats other migraine symptoms like nausea, vomiting etc
  • Helps to return to normal routine due to prompt treatment
  • It effects certain natural substance that cause narrowing of blood vessels in the brain
  • Effective and tolerable
  • Adverse events are mild and moderate
  • Adverse effects last for short duration
  • Safety records and evidence based prescription instruction

SIDE EFFECTS

Some of the common side effects are;

  • Dizziness, injection site reaction
  • Vertigo
  • Nausea and vomiting
  • Flushing sensation
  • Tingling sensation
  • Unpleasant taste
  • Chest discomfort

Major side effects are rare cases. But it is necessary to look for a doctor for any of these symptoms.

  • Nerve pain
  • Severe numbness on one side of the face or body
  • Severe or continuing pain stomach
  • Unusual bleeding
  • Trouble speaking or swallowing
  • Vomiting of blood or material that looks like coffee grounds

PRECAUTIONS

It is necessary to Inform doctor in certain cases as given below:

  1. Allergy to the ingredient in Sumatriptan
  2. History of heart disease, or other blood vessels disease
  3. Uncontrolled high blood pressure or severe liver problem
  4. If one have used certain other migraine medicines in past 24 hours.
  5. History of kidney problem or seizures
  6. Women in past menopause
  7. Man who is older than 40 years
  8. One is overweight

Inform doctor as some medicines can interact with Sumatriptan

COST OF GENERIC VS BRAND DRUG

The cost per pill of Imetrex in USA pharmacy is $5.63 while the generic drug (Sumatriptan) is $2.92 that’s almost half the price. This shows that the difference in cost between the Imitrex and Sumatriptan but both provide the same effect..

 

Carisoprodol (Soma) – Use To Relief Muscle Pains

Carisoprodol is a generic drug marketed under brand name soma. It is an oral muscle relaxant. It gives a short term relief from muscle pain and skeletal condition in adult. It is a white color tablet with a bitter taste.

WORKING:

It modulates the activities of neuro-transmitter in spinal cord and in brain. It blocks pain sensation between nerves and brain. It includes physio therapy to relieve pain . It reduces discomfort caused by stains, sprain and other muscle injuries. It focuses on the nerves that control the muscle. This drug influences the whole CNS. Due to this reason older people can use soma. It can treat other disease which aren’t listed as well.

Carisoprodol

DOSAGE:       

It is available in the form of oral tablet in two strengths

  1. 250 mg
  2. 350 mg

Take three times a day and at bed time. It is a short term course for two or three weeks. Adequate evidence of for long term use aren’t explained. Doctor’s prescribed it at a gap of 6 hours. But the medication can change from one patient to other.

SIDE EFFECTS: 

It is a very well tolerated drug. Though it gives quick relief from acute pain it shows some common side effects. But you  don’t need to worry. They are common as your body tries to adjust to the medicine. They will go away after a few  days.

  • Drowsiness
  • Dizziness
  • Headache
  • Sedation

Some other serious or major side effects that patient can experience . It is necessary to consult doctor regarding this. They are rare cases.

  • Chest pain
  • Chills, cold sweats
  • Cough, fever
  • Confusion, convulsions
  • Faintness
  • Sore throat, ulcers
  • White spots on lips or mouth
  • Shortness of breath
  • Muscle spasm
  • Unusual weakness

ADVANTAGES:

  • It is useful as muscle relaxant
  • It is a safe pain medication
  • One can consume it on an empty stomach
  • Relieves discomfort caused by strains, sprains and muscle injuries
  • Give comfort in against acute pain
  • Aged people can take to get relief from pain. Recent studies show that the elderly can use soma ,same as the younger adults.

DRAWBACKS:        

  • No adequate studies to show adverse effects in pregnancy and breast feeding.
  • It can lead to seizures.
  • It is potential to cause withdrawal symptoms in long term treatment.
  • Some times its use leads to aggression in behavior.
  • It can seek attitude or addiction to this drug.
  • It creates adverse effects with alcohol or drug addiction or abused substances.
  • Over dose may be dangerous
  • It contain sedative properties. This impairs mental and physical abilities required for the work like motor driving.
  • It shows dependence to drug

PRECAUTION:

  • It is necessary to take some precaution in certain cases if;
  • Patient has an unusual allergy to this category of medicine.
  • Takes some other medicine which can interact
  • Person taking alcohol or tobacco along with this medicine
  • Person having kidney disease
  • Liver disease
  • History of seizures

Don’t stop sudden dose of medicine. Avoid driving, using machine or anything else that can be dangerous.

FDA approved above drug in 2007. It is in market since 1959. As of 2015, the cost for a typical course of medication need less than US $ 25. It gives good results in case of muscle pain. But proper use of medicine along with rest and physio-

Finasteride: Side Effects and Advantages for the Treatment of Hair Loss

Finasteride is a drug sold under the brand name propecia. It prevents conversion of testosterone to DHT( a male hormone ) in the body.  It is used for the treatment of hair loss. Male –pattern hair loss is a problem faced by a lot of men. It effects hair loss from the top and the front scalp first. We can see receding hair line in men over the time.

CAUSES:

The effect of male hormone (DHT) on the hair follicles causes male-pattern baldness. It is present in the front, top and crown of the scalp. This hormone shrink the hair follicles both in diameter and length. These effected follicles then produce small hair and unpigmented hair unlike the normal pigmented hair. The hormone affects the growth phase of the susceptible follicle. Due to these two effects, the hair become shorter and shorter and then disappears.

Finasteride

WORKING:

It decreases the male hormone DHT in both scalp and blood vessels. It blocks an enzyme that convert testosterone to DHT. It increases testosterone in blood and supports the hair growth.

DOSAGE:

It available in form of a tablet of 1 mg .Take it with or without food.  Physician advice to take 1 tablet of 1 mg one time in a day and at the same time every day. It is important to continue the dosage for at least 3 months to see effective results. One can face reversal effects on stopping to consume the tablet within 12 months.

ADVANTAGES OF FINASTERIDE:

  1. Use to treat male-pattern baldness.
  2. Use of this can reduce the need for surgery in case of enlarged prostate.
  3. Improve symptoms of BPH.
  4. Benefits in decrease urge to urinate.
  5. Helps to reduce night time urination.

DRAWBACKS:-

  1. Women can’t use this for baldness
  2.  can affect the PSA blood test due to decrease PSA level in blood
  3. It can interact with other drug,
  4. Women shouldn’t handle even the broken tablet in pregnancy,
  5. It increase the risk of prostate cancer after the age of 55
  6. Precaution is necessary in patients with liver function problem,
  7. Propecia is not meant for children,
  8. Stopping to consume tablet will reverse the baldness 

SIDE EFFECTS OF FINASTERIDE:

  1. Decreased volume of ejaculation
  2. Sexual adverse experiences
  3. Weakning
  4. Dizziness
  5. Abnormal ejaculation
  6. Swelling or tenderness in the breast
  7. Skin rashes
  8. Swelling in hands and feet
  9. Trouble having orgasm
  10. Headache

Finasteride

Don’t ignore side effects like breast jumps, pain, nipple discharge, or other breast changes. This may sign of male breast cancer. Some others side effect is pain in testicles and unable to urinate. The side effects may continue till 12 months if you stop taking tablet.

FDA has approved this medicine in 1 mg /day in the brand name of propecia. It is used for the treatment of male-pattern baldness .The results are excellent in case of baldness. But it is necessary to continue the medicine for at least five years. 90% of people (male) taking finasteride experience either growth of new hair or stop the hair loss. One can see a significant improvement in front region of scalp.

 

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