Orlistat is a lipase inhibitor used help very overweight or obese people lose weight. It is prescribed for those people with a body mass of 28 kg per square meter or higher or if they are at a risk factor for obesity-related diseases such as high blood pressure, type-2 diabetes or raised blood cholesterol. Orlistat is used with an individualized low-fat, low-calories diet and exercise program to help obese and overweight people lose weight. It’s also used after a weight loss to help them keep from gaining back loss weight.
Lipase inhibitor like Orlistat works by preventing some of the fat in the foods eaten from being absorbed by the intestines. It’s not absorbed into the bloodstream but works locally in the small intestine and in the stomach. It works by inhibiting the pancreatic and gastric lipases which break down the triglycerides fat in the intestines from the foods you eat.
When this activity is blocked, the fat from your diet is not hydrolyzed into absorbable fatty acids, and instead are excreted unchanged. This reduces the caloric intake and your body cannot use the fat as a source of energy. The unabsorbed fat is then removed from the body in the stool. Orlistat is sometimes prescribed for purposes as determined by your physician.
Orlistat is designed to treat obesity and is marketed in prescription and non-prescription forms. The prescription form is used in obese and overweight people who may also have diabetes, high blood pressure, high cholesterol or heart disease. Orlistat is FDA-approved in the US and marketed under different brand-names. The effectiveness of this medication in promoting weight loss is definite but modest. Those who take Orlistat in addition to lifestyle change such as exercise and diet loses about 2-3 kg more than those who are not taking this medicine.
Orlistat also prevents the onset of type 2 diabetes and reduces blood pressure from weight loss itself and other effect on a long-term use.
Orlistat comes in a capsule form that you need to take orally. Take it exactly as instructed on the label or as directed by your physician. The typical recommended dose is one capsule three times a day with each main meal that contains fat. You can take it during a meal or one hour after a meal.
If you eat a meal that does not contain fats or you have skipped a meal, skip your dose for that meal. The fat content of your diet should not exceed 30% of your total caloric intake. If you eat a meal that is very high in fat, you are more likely to experience side effects as a result of the indigested fat passing through your gut. Do not take more or less than what is prescribed to you. Do not take more than 3 capsules in a day.
For a missed dose take Orlistat 1 hour after a main meal. If it is longer than 1 hour after eating, skip the missed dose and continue with your regular dosing. Do not take to capsules to make up for the missed one. Swallow the capsule whole with water.
Orlistat may cause some side effects. Common side effects are:
Uncommon side effects include:
In case of serious and bothersome side effect, contact your doctor right away.
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